Designing an Alternative to Antibiotics

In 1928 a British scientist made a “chance observation.” He noticed that some mold had grown in a bacterial culture plate in his laboratory. Molds can do that. But this mold had the ability to kill the bacteria around it. 

The scientist, Alexander Fleming, found that the mold was a member of a common group known as Penicillium. Fleming and two other scientists — Ernst Boris Chain and Howard Walter Florey — went on to win the Nobel Prize in 1945. They were honored “for the discovery of penicillin and its curative effect in various infectious diseases.” Other powerful antibiotics have been discovered since penicillin. But many antibiotics have become less and less effective as the germs they are designed to kill develop resistance. So scientists are searching for new ways to treat infections. 

Now, researchers in Australia say they have made an important discovery. Scientists at Monash University in Melbourne believe an antibacterial viral protein called PlyC could be used as an alternative to antibiotics. This protein was first identified as a possible treatment for infections in 1925. But the research ended following the discovery of antibiotics.

Now, scientists have spent six years studying the structure of the protein. They have found how it kills the bacteria that cause sore throats, pneumonia and streptococcal toxic shock syndrome. 

Australian researchers worked with scientists at the Rockefeller University in New York and the University of Maryland. Their findings appear in the Proceedings of the National Academy of Sciences.

Dr. Sheena McGowan of Monash University describes the protein as a powerful bacterial killing machine. She says it looks like a flying saucer carrying a pair of warheads. It connects to the surface of the bacterium and then cuts though the outside to destroy it. Sheena McGowan says it could be highly valuable when conditions like pneumonia do not respond to traditional treatments.

She says some antibiotics are not as effective as they used to be. And she urges that more research be done to develop safe drugs for humans.

The researchers have been studying PlyC’s atomic structure to try to develop a drug. They say they have had success in treating streptococcal infections in mice. But an effective human treatment in the form of a pill or nasal spray may be at least 10 years away.